Strategy, Education, Documentation & IT (SEDI)

Cancer diagnosis and treatment is a global priority, and recent advances in medical technology offer promising opportunities to address these challenges. All of our group’s work addresses topics related to early cancer diagnosis and management, with a focus on the use of biomarkers and advanced technologies involving AI-assisted imaging analysis methods.
Ovarian tumors and gastric cancer are analyzed to better understand tumor behavior, prognostic factors and possible therapeutic interventions. Ovarian cancer research highlights the use of neural networks and deep learning systems for accurate tumor detection and segmentation, contributing to early diagnosis and improved survival rates. In parallel, gastric cancer studies emphasize the importance of biomarkers, both in tissue and soluble form, for early diagnosis, assessment of prognosis and optimization of personalized treatments, including immunotherapy. All these contributions converge towards the creation of precise, minimally invasive and effective solutions for the management of oncological diseases.

Our Research Department specializes in leveraging advanced data analysis and computational intelligence techniques to drive innovations in healthcare. Combining expertise in machine learning, deep learning, oncology, and signal processing, our team excels in transforming raw data into actionable insights. We focus on medical image analysis, feature engineering, and pattern recognition to enhance diagnostic accuracy and treatment planning. By integrating these advanced methodologies, we aim to improve healthcare outcomes and develop robust decision support systems that empower medical professionals in making informed decisions.

Additionally, the members of the Department of Strategy, Education, Documentation, and IT (SEDI) collective carry out activities in the following areas:

Implementation of managerial control standards.
Maintenance and updating of the website www.virology.ro.
Proper functioning of the computing equipment in the institute.
Optimal management of the book and periodical fund.

MIHAELA CHIVU-ECONOMESCU, PhD

SCIENTIFIC RESEARCHER I

Expertise area includes oncology, immunotherapy, Intracellular signaling, targeted antitumor therapy, immunology, and immune response during

LORETTA ICHIM, PhD

SCIENTIFIC RESEARCHER III

Expertise area includes: machine learning and deep learning approach for medical image analysis, feature engineering,

Demonstration of intelligent decision support for pandemic crisis prediction and management within and across European borders

Acronym: STAMINA

Strategy, Education, Documentation & IT (SEDI) Publications

Preda M., Tanase B.C., Zob D.L., Gheorghe A.S., Lungulescu C.V., Dumitrescu E.A., Stanculeanu D.L., Manolescu L.S.C., Popescu O., Ibraim E., Mahler B. The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer. International Journal of Environmental Research and Public Health 2023, 20, doi:10.3390/ijerph20021282.

39. El-Khatib M., Popescu D., Teodor O., Ichim L. Intelligent system based on multiple networks for accurate ovarian tumor semantic segmentation. Heliyon Sep 2024, 10, doi:10.1016/j.heliyon.2024.e37386.

38. El-Khatib M., Popescu D., Teodor O.M., Ichim L. New trends in ovarian cancer diagnosis using deep learning: A systematic review. IEEE Access Sept 2024, 12, 116587-116608, doi:10.1109/access.2024.3434722.

37. Ichim L., Dinu S., Popescu D. Decision fusion-based system for automatic face emotions recognition. Proceedings of the Intelligent Systems Conference (IntelliSys), April 2024, pp. 743-757, doi:10.1007/978-3-031-47724-9_49

36. El-Khatib M., Teodor O.M., Popescu D., Ichim L. Identification of benign tumor masses using deep learning techniques based on semantic segmentation. In Proceedings of the 17th International Work-Conference on Artificial Neural Networks (IWANN), Ponta Delgada, PORTUGAL, Jun 19-21, 2023; pp. 529-540.

35. Ichim L., Mitrica R.I., Serghei M.O., Popescu D. Detection of malignant skin lesions based on decision fusion of ensembles of neural networks. Cancers (Basel) Oct. 2023, 15, doi:10.3390/cancers15204946.

34. Preda M., Manolescu L.S.C., Chivu R.D. Advances in alpha herpes viruses vaccines for human. Vaccines (Basel) 2023, 11, doi:10.3390/vaccines11061094.

33. Pirlog C.F., Costache R., Parosanu A.I., Slavu C.O., Olaru M., Popa A.M., Iaciu C., Nita I., Motatu P., Cotan H.T., Oprita A.V., Costache D., Manolescu L.S.C., Nitipir C. Restricted mean survival time-can it be a new tool in assessing the survival of non-small cell lung cancer patients treated with immune checkpoint inhibitors? Diagnostics (Basel) 2023, 13, doi:10.3390/diagnostics13111892.

32. Zugravu C.A., Medar C., Manolescu L.S.C., Constantin C. Beer and microbiota: Pathways for a positive and healthy interaction. Nutrients 2023, 15, doi:10.3390/nu15040844.

31. Preda M., Tanase B.C., Zob D.L., Gheorghe A.S., Lungulescu C.V., Dumitrescu E.A., Stanculeanu D.L., Manolescu L.S.C., Popescu O., Ibraim E., Mahler B. The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer. International Journal of Environmental Research and Public Health 2023, 20, doi:10.3390/ijerph20021282.

30. Preda M., Dinu R.S., Prasacu I., Manolescu L.S.C. SARS-CoV-2 Infection Anxiety, Knowledge and Attitudes in University Degree Pregnant Women from Romania-A Cross-Sectional Observational Survey in the First Two Pandemic Years. Vaccines 2023, 11, doi:10.3390/vaccines11010035.

29. Manolescu L.S.C., Zugravu C., Zaharia C.N., Dumitrescu A.I., Prasacu I., Radu M.C., Letitia G.D., Nita I., Cristache C.M., Gales L.N. Barriers and Facilitators of Romanian HPV (Human Papillomavirus) Vaccination. Vaccines 2022, 10, doi:10.3390/vaccines10101722.

28. Preda M., Manolescu L.C.S. Romania, a Harbour of HIV-1 Subtype F1: Where Are We after 33 Years of HIV-1 Infection? Viruses-Basel 2022, 14, doi:10.3390/v14092081.

27. Otelea M.R., Zugravu C., Rascu A., Arghir O.C., Manolescu L.S.C., Mates D. Coronasomnia in Employees without a Direct Contact with COVID-19 Infected Patients in Their Workplace. Healthcare 2022, 10, doi:10.3390/healthcare10071194.

26. Radu M.C., Manolescu L.S., Chivu R., Zaharia C., Boeru C., Pop-Tudose M.E., Necsulescu A., Otelea M. Pregnancy in Teenage Romanian Mothers. Cureus Journal of Medical Science 2022, 14, doi:10.7759/cureus.21540.

25. Pirlog C.F., Parosanu A.I., Slavu C.O., Olaru M., Popa A.M., Iaciu C., Nita I., Motatu P., Horia C., Manolescu L.S.C., Nitipir C. Nivolumab Hypersensitivity Reactions a Myth or Reality in Solid Tumors-A Systematic Review of the Literature. Current Oncology 2022, 29, 9428-9436, doi:10.3390/curroncol29120741.

24. Manolescu L.S.C., Zaharia C.N., Dumitrescu A.I., Prasacu I., Radu M.C., Boeru A.C., Boidache L., Nita I., Necsulescu A., Medar C., Cristache C.M., Chivu R.D. COVID-19 Parental Vaccine Hesitancy in Romania: Nationwide Cross-Sectional Study. Vaccines 2022, 10, doi:10.3390/vaccines10040493.

23. Manolescu L.S.C., Zaharia C.N., Dumitrescu A.I., Prasacu I., Radu M.C., Boeru A.C., Boidache L., Nita I., Necsulescu A., Chivu R.D. Early COVID-19 Vaccination of Romanian Medical and Social Personnel. Vaccines 2021, 9, doi:10.3390/vaccines9101127.

22. Radu M.C., Dumitrescu A.I., Zaharia C., Boeru C., Pop-Tudose M.E., Iancu C.F., Chivu R.D. Teenage Pregnancies and Childbirth Experience in Romania From the Midwives Point of View. Cureus Journal of Medical Science 2021, 13, doi:10.7759/cureus.13851.

21. Radu M.C., Boeru C., Pop-Tudose M.E., Necsulescu A., Dumitrescu A., Iancu C.F., Nita I., Limbau A.M., Zaharia C. Human Papillomavirus Infection at the Time of Delivery. Cureus 2021, 13, doi:10.7759/cureus.15364.

20. Zgura I., Beica T., Frunza S., Frunza L., Ganea P., Ungureanu F., Negrila C., Nuta A., Sorescu A.A., Bunea I., Zaharia C.N. Nanostructured SiOx layers as substrates for liquid crystal local ordering. I. Functionalization to bind Bovine Serum Albumin. Optoelectronics and Advanced Materials-Rapid Communications 2011, 5, 318-323.

19. Galatescu A., Alexandru A., Zaharia C., Popovici A. Semantics and Knowledge-based System for Occupational Health Safety. Studies in Informatics and Control 2011, 20, 107-120.

18. Galatescu A., Alexandru A., Zaharia C., Kovacs S. Ontology-based Modeling and Inference for Occupational Risk Prevention. In Proceedings of the 4th International Conference on Advances in Semantic Processing (SEMAPRO), Florence, ITALY, Oct 25-30, 2010; pp. 205-210.

17. Zgura I., Beica T., Frunza S., Rasoga O., Galca A., Frunza L., Moldovan A., Dinescu M., Zaharia C. Nanostructured gold layers. II. Gold deposition onto polystyrene substrate. Journal of Optoelectronics and Advanced Materials 2010, 12, 354-359.

16. Beica T., Frunza S., Zgura I., Frunza L., Cotarlan C., Negrila C., Vlaicu A.M., Zaharia C.N. Nanostructured gold layers. I. Deposition by Vacuum evaporation at small angles of incidence. Journal of Optoelectronics and Advanced Materials 2010, 12, 347-353.

15. Zgura I., Beica T., Frunza S., Frunza L., Cotirlan-Simioniuc C., Ungureanu F., Gheorghe N., Rasoga O., Velula T., Zaharia C. Nanostructured gold layers. III. Functionalization of gold layers obliquely deposited onto polystyrene substrate. Journal of Optoelectronics and Advanced Materials 2010, 12, 1729-1738.

14. Zaharia C.N., Cristea A. A micropopulational modelling of a viral epidemic by using a special neural network. In Proceedings of the 15th Medical Informatics Europe Conference (MIE 99), Ljubljana, Slovenia, Aug, 1999; pp. 682-685.

13. Zaharia C.N., Cristea A., Ciuca I., Moisil I. From a complex neural network with many components to an aggregated simpler neural network. In Proceedings of the 3rd International Conference on Neural Networks and Expert Systems in Medicine and Healthcare, Pisa, Italy, Sep 02-04, 1998; pp. 109-115.

12. Cristea A., Zaharia C.N., Ciuca I. Simulation of a micropopulational epidemic evolution using a special neural network. In Proceedings of the 3rd International Conference on Neural Networks and Expert Systems in Medicine and Healthcare, Pisa, Italy, Sep 02-04, 1998; pp. 133-139.

11. Cristea A., Zaharia C.N., Simionescu I. Simulation by neurocomputing of the local quasi-independent epidemics evolution and of their composition in an overall viral epidemics. In Proceedings of the 10th European Simulation Multiconference, Budapest Univ Econ Sci, Budapest, Hungary, Jun 02-06, 1996; pp. 1079-1083.

10. Cristea A., Zaharia C.N. OBJECTS, INTERACTIONS AND PROCESSES ORIENTED DATA OR KNOWLEDGE – BASES. In Proceedings of the 2nd International Conference on Concurrent Engineering and Electronic Design Automation, Bournemouth, England, Apr 07-08, 1994; pp. 337-342.

9. Zaharia C.A., Marcus E. USE OF FLUORESCAMINE FOR THE DETERMINATION OF THE MOLECULAR FLEXIBILITY OF IMMUNOGLOBULIN BY FLUORESCENCE DEPOLARIZATION. Revue Roumaine De Biochimie 1982, 19, 301-307.

8. Zaharia C.N., Horer O.L., Tarabasanumihaila C., Giurgea M. SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC INVESTIGATION OF AGGREGATION OF SOME ANTHRAQUINONE DERIVATIVES. Talanta 1979, 26, 65-66, doi:10.1016/0039-9140(79)80159-9.

7. Tarabasanumihaila C., Zaharia C., Floru L., Urseanu F., Marculescu B. HETEROCYCLIC COMPACT CONDENSED SYSTEMS .4. LINEAR BIS PYRAZOLO 2,3-D , 8,9-D TRANS-QUINACRIDONE. Revue Roumaine De Chimie 1978, 23, 1079-1084.

6. Zaharia C.N., Tarabasanumihaila C. ASSAY OF INTERACTION BETWEEN SOME NEW AROMATIC-COMPOUNDS AND PROTEINS. Revue Roumaine De Biochimie 1977, 14, 219-224.

5. Zaharia C.N. STEREOFLUORIMETRIC ANALYSIS OF EXCITATION AND EMISSION IN A FLUORESCENT SAMPLE. Studii Si Cercetari De Fizica 1977, 29, 643-646.

4. Zaharia C., Tarabasanumihaila C. SOME ASPECTS CONCERNING INTERACTIONS OF ORGANIC-MOLECULES IN SOLUTION. REVISTA DE CHIMIE 1977, 28, 1042-1045.

3. Horer O.L., Zaharia C.N., Marcu A. TERBIUM FLUORESCENCE IN AQUEOUS-SOLUTIONS OF NUCLEIC-ACIDS. Revue Roumaine De Biochimie 1977, 14, 175-179.

2. Zaharia C.N., Tarabasanumihaila C. ABSORPTION AND EMISSION ELECTRONIC-TRANSITIONS OF QUINACRIDONIC CHROMOPHORE – INFLUENCE OF SOME STRUCTURAL AND MEDIUM FACTORS. Revue Roumaine De Physique 1976, 21, 359-370.

1. Zaharia C.N., Tarabasanumihaila C. SPECTRAL STUDIES OF SOME LINEAR TRANS-QUINACRIDONIC DERIVATIVES – ELECTRONIC-SPECTRA. Revue Roumaine De Physique 1975, 20, 769-780.