Proteomic screening of bronchoscopic biopsies-on-chip for improved prediction of anti-PD-1 responses in real-time

Acronym: BronchoBOC

ERAPERMED2019-217), Contract no 140/2020

  • 2020-2023
    Acronym: BronchoBOC
    Title: “Proteomic screening of bronchoscopic biopsies-on-chip for improved prediction of anti-
    PD-1 responses in real-time”
  • international network ERAPerMed _ Joint Transnational Call for for Personalised
    Medicine: Multidisciplinary Research Towards Implementation”
    Partners:
  • Consortium leader: Institute of Bioinovation BSRC “Alexander Fleming”, Vari, Greece
    (project leader Dr. Maria Tsoumakidou)
  • Romanian project leader: dr. Viviana Roman, Ph.D (Senior Researcher)

Funding for IVN/CIB: 137.000 Euro
Working team from IVN/CIB: dr. Viviana Roman, dr. Marinela Bostan
Project Aims:

  • Collection of clinical, LC-MS/MS, FACS, CBA and
    imaging data for predictive modelling
  • Development of a predictive classifier based on integrative proteomics and imaging data
  • Delivery of an easy-to-use predictive tool
  • Establishing communication channels to assist
    dissemination to scientific community
  • Conceptualize a budget impact model and a cost effectiveness model

Results:

  1. V. ROMAN, M. MIHAILA, N. RADU,   S. MARINEATA, C.C. DIACONU, M.
    BOSTAN. Cell culture model evolution and its impact on improving  therapy efficiency
    in lung cancer. Cancers, 15, 2023 (in press)
  2. V. ROMAN, M. MIHAILA AND M. BOSTAN Comparative study design between cell
    culture types for therapy application. 2 nd Edition of the OncoHub Conference Connecting
    Scientists and Physicians for Next Generation Cancer Management, 21- 23 septembrie
    2022, Poiana Brasov, Romania
  3. V. ROMAN, M. MIHAILA, S. MARINEATA, N. RADU AND M. BOSTAN. New
    approaches to improve the efficacy of drug response in lung cancer. Congress of the
    Institute of Oncology, Iasi (oral presentation), November 23 – 26, 2022
  4. V. ROMAN, M. MIHĂILĂ, Ș. MARINEATĂ, N. RADU , M. BOSTAN. Different study
    models to improve lung cancer response to therapy. “Inovație și Multidisciplinaritate în
    Tratamentul Cancerului”, Al 33-lea Congres al Societății Române de Radioterapie și
    Oncologie Medicală și Congresul Societății Române de Radioterapie, Sinaia, Hotel
    International, October 13 – 16, 2022

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