PN-III-P2-2.1-PED2019-5143, 383PED
Title: Development of anticancer nanoparticulate systems based on novel metal complexes
(acronym FLAVONAN), 2020 – 2022
Partners:
Project leader CO – Stefan S. Nicolau Institute of Virology (350000 lei), project CO director dr.
Mirela Mihaila
Project partner P1 – Faculty of Pharmacy from Carol Davila University of Medicine and
Pharmacy project P1 director Prof. Valentina Uivarosi
Funding: 600000 lei (CO – 350000 lei; P1 – 250000 lei)
Working team: Mirela Mihaila, Lorelei Irina Brasoveanu, Marinela Bostan, Mia Camelia
Hotnog, Viviana Roman, Aneta Doncea
Abstract: The project was a complex, interdisciplinary study linked to the interests of
international biomedical research, which aimed to bring new anticancer agents closer to clinical
trials, making a translation from the chemical substance to the pharmaceutical product.
Pharmaceutical development is a complex and laborious process that begins with studies of the
dissolution and release of the active substance from the pharmaceutical product and continues
with studies on the pharmacokinetics, pharmacological activity and side effects of the product.
Aims: to develop and validate new liposomal systems for the transport and delivery of 2
promising anti-cancer agents. Nanoparticle drug carrier systems offer great promise to improve
the therapeutic efficacy and safety profile of these novel anticancer agents. The efficiency of
these nanoformulations was evaluated in terms of stability, drug entrapment efficiency, release
behavior, cellular uptake, cytotoxicity, pharmacotoxicological profile.
Results:
- Mirela Mihaila, Camelia Mia Hotnog, Marinela Bostan, Alexandra Cristina Munteanu, Ileana
Adela Vacaroiu, Lorelei Irina Brasoveanu, Valentina Uivarosi. Anticancer activity of some
ruthenium (III) complexes with quinolone antibiotics: In vitro cytotoxicity, cell cycle
modulation, and apoptosis-inducing properties in LoVo colon cancer cell line. Appl. Sci., 11(18),
8594-8613, 2021, doi.org/10.3390/app11188594 - Valentina Uivarosi, Alexandra Cristina Munteanu, Mihaela Badea, Rodica Olar. Metal
Complexes of Plant Secondary Metabolites with Therapeutic Potential. Plant Secondary Metabolites. Physico-Chemical Properties and Therapeutic Applications. Springer, 978-981-16-4778-9, 2022 - Alexandra Cristina Munteanu, Valentina Uivarosi. Ruthenium Complexes in the Fight against
Pathogenic Microorganisms. An Extensive Review. Pharmaceutics, 13(6), 2021,
doi.org/10.3390/pharmaceutics13060874 - Mirela Mihăilă, Marinela Bostan, Camelia Hotnog, Viviana Roman, Lorelei I. Brașoveanu,
Alexandra-Cristina Munteanu, Valentina Uivaroși. Biological activity of the metal complexes in
different tumor cell lines. 2 nd Edition of the OncoHub Conference Connecting Scientists and
Physicians for Next Generation Cancer Management, 21- 23 septembrie 2022, Poiana Brasov,
Romania - Alexandra-Cristina Munteanu, Anca Ungurianu, Denisa Margina, Mirela Mihaila, Ariana
Hudita, Bianca Galateanu, Valentina Uivarosi. Effects of metal coordination on the antioxidant
and cytotoxic properties of the natural flavonoid primuletin. 2 nd Edition of the OncoHub
Conference Connecting Scientists and Physicians for Next Generation Cancer Management, 21-
23 septembrie 2022, Poiana Brasov, Romania - Mirela Mihăilă, Marinela Bostan, Camelia Hotnog, Viviana Roman, Lorelei I. Brașoveanu,
Alexandra-Cristina Munteanu, Valentina Uivaroși. Evaluation of anti-tumor activity of the metal
complexes on colon and ovarian cancer cell lines. “Inovație și Multidisciplinaritate în
Tratamentul Cancerului” Al 33-lea Congres al Societății Române de Radioterapie și Oncologie
Medicală și Congresul Societății Române de Radioterapie, Sinaia, Hotel International, 13 – 16
octombrie 2022 - Alexandra-Cristina Munteanu, Mirela Mihaila, George Mihai Nitulescu, Valentina Uivarosi.
Ruthenium (II) octahedral complexes featuring pyrimidine-like ligands: cytotoxicity and
DNA/protein interaction studies. GP2A 2021 – 29th Annual Conference, 25-27.08.2021 - Alexandra-Cristina Munteanu, Mirela Mihaila, Joseph Cowell, Gilles Gasser, Valentina
Uivarosi. Osmium (II) octahedral complexes featuring orotic acid: anticancer activity and
DNA/protein interaction studies, 1st OncoHub Conference, 13-15.10.2021
