Evaluation of COL10A1 as a potential therapeutic target and early diagnostic biomarker in gastric cancer

Acronym: COL-DIA-THER
Principal investigator: Laura Necula PhD

(2020-2022; PN-III-P1-1.1-TE-2019) – Principal investigator: Laura Necula PhD

Aim: The main objective was to analyze the involvement of COL10A1 in gastric carcinogenesis in order to evaluate its potential as a biomarker for the diagnosis of gastric cancer and molecular target for the development of new therapeutic strategies.

Coordinator: Institute of Virology Stefan S. Nicolau – principal investigator Dr. Laura Georgiana Necula

Funding: 431.900 RON

Working team: Laura Georgiana Necula, Mihaela Economescu, Lilia Matei, Denisa Dragu, Ioana Pitica.

Project financed by UEFISCDI program PN-III-P1-1.1-TE-2019, contract no. TE36/2020

Implementation period: 01.09.2020 – 30.08.2022

Summary: The results obtained within this project regarding the correlation between the increased circulating COL10A1 level and tumor progression suggest the possibility of using COL10A1 as a diagnostic and prognostic biomarker in patients with gastric cancer. Also, the results related to the involvement of COL10A1 in tumor development processes such as proliferation, suppression of apoptosis and invasion of gastric cells can significantly influence the scientific field, suggesting that this molecule could represent a therapeutic target. In conclusion, the results obtained in this study could represent the basis for the development of new methods of prevention, diagnosis and treatment of patients with gastric cancer, improving the survival rate in the case of this disease.

Results:

Articles:

  1. Chivu-Economescu M, Necula LG, Matei L, Dragu D, Bleotu C, Sorop A, Herlea V, Dima S, Popescu I, Diaconu CC. Collagen Family and Other Matrix Remodeling Proteins Identified by Bioinformatics Analysis as Hub Genes Involved in Gastric Cancer Progression and Prognosis. International Journal of Molecular Sciences 2022; 23(6):3214. https://doi.org/10.3390/ijms23063214 IF=6.208/2021
  2. Necula L, Matei L, Dragu D, Pitica I, Neagu A, Bleotu C, Diaconu CC, Chivu-Economescu M. Collagen Family as Promising Biomarkers and Therapeutic Targets in Cancer. Int. J. Mol. Sci. 2022, 23, 12415. https://doi.org/10.3390/ijms232012415 IF=6.208/2021