Health Program
- Call Code: PS/272/PS_P5/OP1/RSO1.1/PS_P5_RSO1.1_A9
- Call Title: Support for the implementation of research solutions of strategic importance in the medical field: genomics; non-communicable diseases (e.g., development of research solutions for cancer treatment); vaccines, serums, and other biological medicines
- Fund: European Regional Development Fund
- Project Code: 324809
- Project Title: Development of Genomic Research in Romania (ROGEN)
- Beneficiary: “CAROL DAVILA” University of Medicine and Pharmacy, Bucharest
- Partner (P5): “Stefan S. Nicolau” Institute of Virology, Romanian Academy, Bucharest
- Total Budget: 422,304,303.91 RON, of which the European Regional Development Fund (approximately 51%) is 214,096,622 RON, the State Budget (approximately 49%) is 207,586,978 RON, and the private sector (SMEs – 0.1%) contributes 620,703.32 RON.
- Budget for IVN: 21,424,683.08 RON
Publications:
- Dragu D, Necula LG, Bleotu C, Diaconu CC, Chivu-Economescu M. Soluble PD-L1: From Immune Evasion to Cancer Therapy. Life (Basel). 2025 Apr 8;15(4):626. https://doi.org/10.3390/life15040626
- Dragu LD, Chivu-Economescu M, Pitica IM, Matei L, Bleotu C, Diaconu CC, Necula LG. Targeting Exosomal PD-L1 as a New Frontier in Cancer Immunotherapy. Curr Issues Mol Biol. 2025 Jul 8;47(7):525. https://doi.org/10.3390/cimb47070525
- Neagu AI.; Bostan M.; Ionescu VA.; Gheorghe G.; Hotnog CM.; Roman V.; Mihaila M.; Stoica SI; Diaconu CC.; Diaconu CC.; Ruta SM., Bleotu C. The Impact of the Microbiota on the Immune Response Modulation in Colorectal Cancer. Biomolecules 2025, 15, 1005. https://doi.org/10.3390/biom15071005
- Matei L., Chivu-Economescu M., Dragu L.D., Grancea C., Bleotu C., Hrisca R., Popescu C.P., Diaconu C.C., Ruta S.M. Long-term durability and variant-specific modulation of SARS-CoV-2 humoral and cellular immunity over two years. International Journal of Molecular Sciences Aug 21 2025, 26, https://doi.org/10.3390/ijms26168106
- Radu E., Fertig T.E., Dragu L.D., Pitica I.M., Surleac M., Neagu A.I., Pana L., Pais A., Matei L., Antone-Iordache I., Marta D.S., Peteu V., Nita-Lazar M., Stoica C., Popescu C., Sultana C.M., Botezatu A., Iancu I.V., Chivu-Economescu M., Banica L., Petre A.S., Paraschiv S., Gherghiceanu M., Ruta S.M., Kreuzinger N., Diaconu C.C., Bleotu C. Monitoring SARS-CoV-2 dissemination in wastewater and virus isolation in cell cultures: An integrated approach for pathogen detection and surveillance. Journal of Cellular and Molecular Medicine Sep 1 2025. 29.https://doi.org/10.1111/jcmm.70805
- Hotnog C.M., Bostan M., Anghelescu M., Roman V., Bleotu C., Hainarosie R., Voiosu C., Marineata S., Bostan I.S., Diaconu C.C., Mihaila M. Long non-coding RNAs: Significant drivers of carcinogenesis mechanisms in head and neck squamous cell carcinoma. Current Issues In Molecular Biology Aug 28 2025, 47 https://doi.org/10.3390/cimb47090698
- Ionescu, V.A.; Gheorghe, G.; Bleotu, C.; Puiu, L.; Mambet, C.; Diaconu, C.C.; Diaconu, C.C. Circulating miRNAs as Non-Invasive Biomarkers in Pancreatic Cancer: A Two-Phase Plasma-Based Study. J. Clin. Med. 2025, 14, 6430. https://doi.org/10.3390/jcm14186430
- Albulescu, A.; Fudulu, A.; Mihaila, M.A.; Iancu, I.; Plesa, A.; Bostan, M.; Botezatu, A.; Brasoveanu, L.I.; Hotnog, C.M. Epigenetic Remodeling in Thyroid Cancer: New Dimensions of Targeted Therapy Through lncRNA Modulation. Curr. Issues Mol. Biol. 2025, 47, 863. https://doi.org/10.3390/cimb47100863
