Molecular Virology

The Department of Molecular Virology has a long research tradition in the Human Papilloma Virus (HPV) induced oncogenesis. The department also initiated the study of epigenetics through several research approaches.

The main interests are: the evaluation of epigenetic markers and non-coding RNA in different pathologies (cervical, laryngeal, breast, thyroid, and pancreatic cancer, rare diseases, male infertility, and cardiovascular diseases). Important chromatin remodeling studies were carried out by investigating the involvement of various enzymes and their complexes through Next Generation Sequencing (NGS) and molecular techniques. During the SARS-CoV2 pandemic, the department was involved in the diagnosis of SARS-CoV2 infection and evaluated the dynamics of SARS-CoV2 genome mutations and viral variants throughout the pandemic waves. The members of the department are also involved in the training and guidance of young PhD students, as well as resident doctors specialized in microbiology and epidemiology, in NGS and molecular biology techniques.

ANCA BOTEZATU is scientific researcher I and Head of Molecular Virology Department. Expertise area includes:
ADRIANA PLESA is scientific researcher II at Molecular Virology Department. Expertise area includes animal cell
IULIA VIRGINIA IANCU is scientific researcher II at Molecular Virology Department. Expertise area includes basic
IRINA HUICĂ is scientific researcher III at Molecular Virology Department. Expertise area includes, genetic engineering,
ALINA FUDULU is scientific researcher at Molecular Virology Department. Expertise area includes: cell culture, PCR
Adrian Albulescu is scientific researcher in the Molecular Virology Department. Expertise area includes cell cultures,
Botezatu A., Vladoiu S., Fudulu A., Albulescu A., Plesa A., Muresan A., Stancu C., Iancu I.V., Diaconu C.C., Velicu A., Popa O.M., Badiu C., Dinu-Draganescu D. Advanced molecular approaches in male infertility diagnosis(dagger). Biology of Reproduction 2022, 107, 684-704, doi:10.1093/biolre/ioac105.

156. Gurban P., Mambet C., Botezatu A., Necula L.G., Matei L., Neagu A.I., Pitica I., Ataman M., Tatic A., Bardas A., Gaman M.A., Dobrea C., Dragomir M., Ghimici C., Angelescu S., Barbu D., Stanca O., Danila M., Berbec N., Colita A., Vladareanu A.M., Nedeianu S., Chivu-Economescu M., Bleotu C., Coriu D., Sepulchre E., Anton G., Diaconu C.C., Constantinescu S.N. Dominance of mutations in epigenetic regulators and a diversity of signaling alterations in blast-phase BCR::ABL1-negative myeloproliferative neoplasms. American Journal Of Hematology Oct. 2024, doi:10.1002/ajh.27503. IF=10.1; Q1

155. Fudulu A., Bostan M., Iancu I.V., Plesa A., Albulescu A., Stoian I.L., Socolov D.G., Anton G., Botezatu A. Assessing the methylation status of two potential key factors involved in cervical oncogenesis. Reports Sep 2024, 7, doi:10.3390/reports7030071. IF=0.8; Q3

154. Gurban P., Mambet C., Botezatu A., Necula L.G., Matei L., Neagu A.I., Pitica I.M., Dragu L.D., Schulman A.N., Ataman M., Nedeianu S., Chivu-Economescu M., Bleotu C., Anton G., Diaconu C.C. Increased mRNA expression for serotonin receptor 1B (HTR1B) is associated with thrombosis in BCR::ABL1-negative myeloproliferative neoplasms. Journal of Cellular and Molecular Medicine Aug 2024, 28, doi:10.1111/jcmm.70024. IF=4.3; Q2

153. Gaman M.A., Mambet C., Neagu A.I., Bleotu C., Gurban P., Necula L., Botezatu A., Ataman M., Diaconu C.C., Ionescu B.O., Ghiaur A.E., Tatic A., Coriu D., Gaman A.M., Diaconu C.C. Assessment of total antioxidant capacity, 8-hydroxy-2′-deoxy-guanosine, the genetic landscape, and their associations in BCR::ABL-1-negative chronic and blast phase myeloproliferative neoplasms. International Journal of Molecular Sciences Jun 2024, 25, doi:10.3390/ijms25126652. IF=4.9; Q1

152. Albulescu A., Fudulu A., Iancu I.V., Plesa A., Dinu-Draganescu D., Vladoiu S., Botezatu A. Epigenetic profiling of male infertility: Investigating the expressions of HAR1B, MEG3, MALAT1, and EZH2. FEBS Open Bio Jun. 2024, 14, 127-127. IF=2.8; Q3

151. Fudulu A., Iancu I.V., Albulescu A., Plesa A., Stoian I.L., Socolov D.G., Botezatu A. Chromatin remodeling dynamics in HPV infection: Evaluating gene expression profile. FEBS Open Bio Jun. 2024, 14, 250-251. IF=2.8; Q3

150. Miu D.M., Sha’at F., Neagu G., Albulescu A., Pavaloiu R.D., Eremia M.C., Jinga S.I. Biopolymer nanoparticles loaded with curcumin for biomedical applications. University Politehnica of Bucharest Scientific Bulletin Series B-Chemistry and Materials Science Jun 2024, 86, 173-186. IF=0.3; Q4

149. Fudulu A., Diaconu C.C., Iancu I.V., Plesa A., Albulescu A., Bostan M., Socolov D.G., Stoian I.L., Balan R., Anton G., Botezatu A. Exploring the role of E6 and E7 oncoproteins in cervical oncogenesis through MBD2/3-NuRD complex chromatin remodeling. Genes May 2024, 15, doi:10.3390/genes15050560. IF=2.8; Q2

148. Pirvu L.C., Rusu N., Bazdoaca C., Androne E., Neagu G., Albulescu A. A view on the chemical and biological attributes of five edible fruits after finishing their shelf life: Studies on Caco-2 cells. International Journal of Molecular Sciences May 2024, 25, doi:10.3390/ijms25094848. IF=4.9; Q1

147. Iancu I.V., Diaconu C.C., Plesa A., Fudulu A., Albulescu A., Neagu A.I., Pitica I.M., Dragu L.D., Bleotu C., Chivu-Economescu M., Matei L., Mambet C., Nedeianu S., Popescu C.P., Sultana C., Ruta S.M., Botezatu A. LncRNAs expression profile in a family household cluster of COVID-19 patients. Journal of Cellular and Molecular Medicine Apr 2024, 28, doi:10.1111/jcmm.18226. IF=4.3; Q2

146. Pirvu L.C., Pintilie L., Albulescu A., Stefaniu A., Neagu G. Anti-proliferative potential of cynaroside and orientin-in silico (DYRK2) and in vitro (U87 and Caco-2) studies. International Journal of Molecular Sciences. Dec 2023, 24, doi:10.3390/ijms242316555. IF=4.9; Q1

145. Gurban P., Mambet C., Botezatu A., Necula L.G., Neagu A.I., Matei L., Pitica I.M., Nedeianu S., Chivu-Economescu M., Bleotu C., Ataman M., Mocanu G., Saguna C., Pavel A.G., Stambouli D., Sepulchre E., Anton G., Diaconu C.C., Constantinescu S.N. Leukemic conversion involving Ras mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: A case report. Frontiers in Oncology Sep 2023, 13, doi:10.3389/fonc.2023.1266996. IF=3.5; Q2

144. Catana R.D., Moldoveanu M.M., Mihai R.A., Botezatu A., Albulescu A., Kosakyan A., Florescu L. Screening of phytoresources from the Romanian flora with medical applications against COVID – review. International Journal of Ayurvedic Medicine Jul-Sep 2023, 14, 624-634. IF=0.1; Q4

143. Stoian I.L., Botezatu A., Fudulu A., Ilea C.G., Socolov D.G. Exploring microbiota diversity in cervical lesion progression and HPV infection through 16S rRNA gene metagenomic sequencing. Journal of Clinical Medicine Aug 2023, 12, doi:10.3390/jcm12154979. IF=3; Q1

142. Rugescu I.A., Dumitrescu R., Draganescu D.D., Botezatu A., Albulescu A., Fudulu A., Plesa A., Iancu I.V., Vladoiu S., Badiu C., Stancu C., Muresan A., Popa O., Udrea L. Estradiol levels in idiopathic male infertility. Human Reproduction Jun 2023, 38. IF=6; Q1

141. Pirvu L.C., Neagu G., Albulescu A., Stefaniu A., Pintilie L. Potential benefits of dietary plant compounds on normal and tumor brain cells in humans: In silico and in vitro approaches. International Journal of Molecular Sciences Apr 2023, 24, doi:10.3390/ijms24087404. IF=4.9; Q1

140. Pavel A.G., Stambouli D., Anton G., Gener I., Preda A., Baston C., Gingu C. Cumulative effect assessment of common genetic variants on prostate cancer: Preliminary studies. Biomedicines Nov 2022, 10, doi:10.3390/biomedicines10112733. IF=4.7; Q2

139. Botezatu A., Vladoiu S., Fudulu A., Albulescu A., Plesa A., Muresan A., Stancu C., Iancu I., Diaconu C.C., Velicu A., Popa O.M., Badiu C., Dinu-Draganescu D. Advanced molecular approaches in male infertility diagnosis. Biology of Reproduction Sep 2022, 107, 684-704, doi:10.1093/biolre/ioac105. IF=3.6; Q2

138. Iancu I.V., Botezatu A., Fudulu A., Albulescu A., Huica I., Plesa A. The interplay between long non-coding RNAs expression and DNA methylation in hypoxia. Febs Open Bio Jul 2022, 12, 284-285. IF=2.6; Q4

137. Fudulu A., Botezatu A., Albulescu A., Iancu I.V., Plesa A., Anton G. The influence of inhibitors targeting epigenetic factors in cervical cancer in vitro model. Febs Open Bio Jul 2022, 12, 104-104. IF=2.6; Q4

136. Botezatu A., Fudulu A., Iancu I.V., Bostan M., Mihaila M., Albulescu A., Diaconu C.C., Anton G., Plesa A. Assessment of HPV16 viral oncogenes’ role in genome-wide pattern deposition of MDB2/3 components of NURD nucleosome remodeling complex. Febs Open Bio Jul 2022, 12, 164-164. IF=2.6; Q4

135. Albulescu A., Fudulu A., Botezatu A., Iancu I.V., Plesa A., Brasoveanu L.I. Long noncoding RNA profile in neuroblastoma and glioblastoma. Febs Open Bio Jul 2022, 12, 83-84. IF=2.6; Q4

134. Pavel A.G., Stambouli D., Gener I., Preda A., Anton G., Baston C. Genetic variant located on chromosome 17p12 contributes to prostate cancer onset and biochemical recurrence. Scientific Reports Mar 2022, 12, doi:10.1038/s41598-022-08472-x. IF=4.6; Q2

133. Chivu-Economescu M., Bleotu C., Grancea C., Chiriac D., Botezatu A., Iancu I.V., Pitica I., Necula L.G., Neagu A., Matei L., Dragu D., Sultana C., Radu E.L., Nastasie A., Voicu O., Ataman M., Nedeianu S., Mambet C., Diaconu C.C., Ruta S.M. Kinetics and persistence of cellular and humoral immune responses to SARS-Cov-2 vaccine in healthcare workers with or without prior COVID-19. Journal of Cellular and Molecular Medicine Feb 2022, 26, 1293-1305, doi:10.1111/jcmm.17186. IF=5.3; Q2

132. Botezatu A., Plesa A., Iancu I.V., Bostan M., Mihaila M., Albulescu A., Fudulu A., Diaconu C.C., Anton G. E6 and E7 HPV16 oncogenes influence gene transcription through the genome-wide pattern deposition of MDB2, 3 components of NURD nucleosome remodeling complex. In Proceedings of the EUROPEAN JOURNAL OF HUMAN GENETICS, 2022; pp. 542-542.

131. Hotoboc I.E., Fudulu A., Grigore R., Bertesteanu S., Huica I., Iancu I.V., Botezatu A., Bleotu C., Anton G. The association between lncRNA H19 and Ezh2 expression in patients with EBV-positive laryngeal carcinoma. Acta Otorhinolaryngologica Italica Dec 2021, 41, 537-543, doi:10.14639/0392-100x-n1527.IF=2.618; Q2

130.  Albulescu A., Plesa A., Fudulu A., Iancu I.V., Anton G., Botezatu A. Epigenetic approaches for cervical neoplasia screening (review). Experimental and Therapeutic Medicine Dec 2021, 22, doi:10.3892/etm.2021.10916. IF=2.751; Q3

129. Neagu G., Stefaniu A., Albulescu A., Pintilie L., Pirvu L.C. Antiproliferative activity of Stokesia laevis ethanolic extract in combination with several food-related bioactive compounds; in vitro (Caco-2) and in silico docking (TNKS1 and TNKS2) studies. Applied Sciences-Basel Nov 2021, 11, doi:10.3390/app11219944. IF=2.838; Q2

128. Pavaloiu R.D., Sha’at F., Neagu G., Deaconu M., Bubueanu C., Albulescu A., Sha’at M., Hlevca C. Encapsulation of polyphenols from Lycium barbarum leaves into liposomes as a strategy to improve their delivery. Nanomaterials Aug 2021, 11, doi:10.3390/nano11081938.IF=5.719; Q1

127. Ungureanu C., Socolov D.G., Anton G., Morosan E., Trandafir L.M., Lozneanu L., Trandafirescu M.F., Cojocaru E. Role of Proex C immunocytochemistry in cervical high-grade squamous intraepithelial lesions detection. Romanian Journal of Morphology and Embryology Apr 2021, 62, doi:10.47162/rjme.62.4.15.IF=0.833; Q4

126. Amfim A., Botezatu A., Anton G., Burlibasa L., Zarnescu O., Albu C., Matei M., Tanase A., Radu L.G., Alexandrescu L. Canine model for the study of the epigenetic factors involved in mammary tumor development. Biointerface Research in Applied Chemistry Feb 2021, 11, doi:10.33263/BRIAC111.75437557

125. Fudulu A., Olar R., Maxim C., Scaeteanu G.V., Bleotu C., Matei L., Chifiriuc M.C., Badea M. New cobalt (ii) complexes with imidazole derivatives: Antimicrobial efficiency against planktonic and adherent microbes and in vitro cytotoxicity features. Molecules Jan 2021, 26, doi:10.3390/molecules26010055.IF=4.927; Q3

124. Pitica I.M., Matei L., Dragu L.D., Alexandru G., Suciu A., Alexiu I.D., Neagu A.I., Chivu-Economescu M., Crisan I., Cristina M., Gabriela Anton, Diaconu C.C., Bleotu C. Tamarix gallica extract induces apoptosis via an intrinsic mechanism. Romanian Biotechnological Letters Jul-Aug 2020, 25,doi:10.25083/rbl/25.4/1701.1708.

123. Iancu I.V., Botezatu A., Plesa A., Huica I., Fudulu A., Albulescu A., Bostan M., Mihaila M., Grancea C., Manda D.A., Dobrescu R., Vladoiu S.V., Anton G., Badiu C.V. Alterations of regulatory factors and DNA methylation pattern in thyroid cancer. Cancer Biomarkers May 2020, 28, 255-268, doi:10.3233/cbm-190871.IF=4.388; Q2

122. Marcu A., Colita A., Radu L.E., Jercan C.G., Bica A.M., Asan M., Coriu D., Tanase A.D., Diaconu C.C., Mambet C., Botezatu A., Pasca S., Teodorescu P., Anton G., Gurban P., Colita A. Single-center experience with epigenetic treatment for juvenile myelomonocytic leukemia. Frontiers in Oncology Apr 2020, 10, doi:10.3389/fonc.2020.00484.IF=5.738; Q2

121. Anca B., Iulia V.I., Adriana P., Irina H., Alina F., Adrian A., Gabriela A. Molecular and serological prospects for SARS-Cov-2 epidemiology. Pharmacophore 2020, 11, 122-131.IF=N/A; Q4

120. Pavel A.G., Stambouli D., Gingu C., Preda A., Gener I., Baston C., Anton G. Influences of angiotensin i-converting enzyme gene insertion/deletion polymorphism on prostate cancer risk in Romania. Romanian Biotechnological Letters Nov-Dec 2019, 24,doi:10.25083/rbl/24.6/1043.1049.IF=0.765; Q4

119. Dumitru M., Gruia M.I., Botezatu A., Mihaila M., Hotnog C.M., Hortopan M., Panait M.E., Anton G., Brasoveanu L.I. Her2 Ile655Val polymorphism, EGFR expression and cellular proliferation in urinary bladder carcinomas. Annals of Oncology Nov 2019, 30, doi:10.1093/annonc/mdz413.078.IF=18.274; Q1

118. Mihai S., Codrici E., Popescu I.D., Enciu A.M., Rusu E., Zilisteanu D., Necula L.G., Anton G., Tanase C. Inflammation-related patterns in the clinical staging and severity assessment of chronic kidney disease. Disease Markers Oct 2019, 2019, doi:10.1155/2019/1814304.IF=2.738; Q2

117. Huica I., Iancu I.V., Botezatu A., Plesa A., Socolov D., Teleman S., Anton G. Factors associated with persistence of HPV genital infection in a small cohort of romanian women. Acta Clinica Croatica Sep 2019, 58, doi:10.20471/acc.2019.58.03.02.IF=0.532; Q4

116. Mihai S., Codrici E., Popescu I.D., Enciu A., Albulescu L., Albulescu R., Anton G., Lupu M., Tanase C. Cytokine patterns in chronic kidney disease-mineral and bone disorders. Febs Open Bio Jul 2019, 9, 407-407.IF=2.231; Q3

115. Gurban P., Mambet C., Botezatu A., Necula L.G., Matei L., Mocanu G., Saguna C., Nedeianu S., Chivu-Economescu M., Bleotu C., Lupu A., Anton G., Diaconu C.C., Constantinescu S.N. Type 1 calreticulin mutation in a chronic HCV-infected patient with progressive splenomegaly – NGS as a game changer. Febs Open Bio Jul 2019, 9, 367-367.IF=2.231; Q3

114. Fudulu A., Iancu I.V., Botezatu A., Plesa A., Albulescu A., Huica I., Socolov D., Anton G. Epigenetic mechanism involved in regulation of two immunity factors in cervical cancer. Febs Open Bio Jul 2019, 9, 395-396.IF=2.231; Q3

113. Albulescu A., Diaconu C.C., Fudulu A., Iancu I.V., Botezatu A., Plesa A., Huica I., Socolov D., Brasoveanu I., Anton G. Hada3 mutations in acquisition of hrHPV infection. Febs Open Bio Jul 2019, 9, 159-160. IF=2.231; Q3

112. Plesa A., Socolov D., Huica I., Botezatu A., Iancu I.V., Ungureanu C., Teleman S., Albulescu A., Fudulu A., Anton G. High-risk human papillomaviruses distribution in Romanian women with negative cytology. Journal of Infection in Developing Countries Apr 2019, 13,doi:10.3855/jidc.11103.IF=0.703; Q4

111. Botezatu A., Iancu I.V., Plesa A., Manda D., Popa O., Bostan M., Mihaila M., Albulescu A., Fudulu A., Vladoiu S.V., Huica I., Dobrescu R., Anton G., Badiu C. Methylation of tumour suppressor genes associated with thyroid cancer. Cancer Biomarkers Apr 2019, 25, 53-65, doi:10.3233/cbm-182265.IF=3.436; Q2

100. Hotnog C.M., Mihaila M., Puiu L., Botezatu A., Roman V., Popescu I.D., Bostan M., Brasoveanu L.I. Modulation of the interplay between p53, ICAM-1 and VEGF in drug-treated LoVo colon cancer cells. Romanian Biotechnological Letters Mar-Apr 2019, 24, doi:10.25083/rbl/24.2/261.270.IF=0.765; Q4

109. Bleotu C., Socolov D., Stanculescu R., Socolov R., Anton M., Anton G. Methods of investigation of human microbiome in obstetrics and gynecology. Romanian Biotechnological Letters Mar-Apr 2019, 24, doi:10.25083/rbl/24.2/344.353.IF=0.765; Q4

108.  Stanislav A.A., Vassu-Dimov T., Iacob M.M., Botezatu A., Arsene C., Burlibasa L., Bodron P., Sarghie L., Cucu N., Alexandrescu L. Investigation of fat mass and obesity associated (FTO) gene polymorphism in romanian population. Biointerface Research in Applied Chemistry Dec 2018, 8, 3710-3718.

107. Botezatu A., Iancu I.V., Plesa A., Socolov D., Anton G. DNA methyltransferases and mbd genes expression levels in HPV-induced cervical lesions. European Journal of Human Genetics Oct 2018, 26, IF=3.650; Q2

106. Mihai S., Codrici E., Popescu I.D., Enciu A.M., Albulescu L., Necula L.G., Mambet C., Anton G., Tanase C. Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome. Journal of Immunology Research Sept 2018, 2018:2180373. doi: 10.1155/2018/2180373,IF=3.404; Q2

105. Diaconu C.C., Mambet C., Necula L.G., Gurban P., Matei L., Aldea-Pitica I.M., Neagu A.I., Botezatu A., Bleotu C., Chivu-Economescu M., Roman V., Coriu D., Constantinescu S. Triple negative myeloproliferative neoplasms – sometimes driver mutations stay low-key in plain sight. Romanian Biotechnological Letters Jul-Aug 2018, 23, doi:10.26327/rbl2017.12.IF=0.590; Q4

104. Bleotu C., Matei L., Dragu L.D., Grigorescu L., Diaconu C.C., Anton G. Methods for plant genetic modification; In Genetically Engineered Foods. Handbook of Food Bioengineering, 2018, 6, doi:10.1016/B978-0-12-811519-0.00015-7

103. Iancu I.V., Anton G., Botezatu A., Huica I., Nastase A., Socolov D.G., Stanescu A.D., Dima S.O., Bacalbasa N., Plesa A. Linc01101 and linc00277 expression levels as novel factors in HPV-induced cervical neoplasia. Journal of Cellular and Molecular Medicine Dec 2017, 21, 3787-3794, doi:10.1111/jcmm.13288.IF=4.302; Q1

102. Simona M., Codrici E., Popescu I.D., Enciu A., Albulescu R., Codorean E., Rusu E., Zilisteanu D., Anton G., Tanase C. Protein profiling in chronic kidney disease assessed by high-throughput technologies. Febs Journal Sep 2017, 284, S1,135-135.IF=4.530; Q1

101. Plesa A., Botezatu A., Iancu I.V., Pitica I., Socolov D., Anton G. Moz/Morf complex components expression levels in HPV-cervical cancer. Febs Journal Sep 2017, 284, S1, 225-225.IF=4.530; Q1

100. Iancu I.V., Botezatu A., Plesa A., Socolov D., Anton G. Long non-coding RNAs expression pattern in cervical oncogenesis. Febs Journal Sep 2017, 284, S1, 222-222.IF=4.530; Q1

99. Botezatu A., Iancu I.V., Plesa A., Socolov D., Anton G. The effect of hrHPV infection on DNA methylation process during cervical oncogenesis. Febs Journal Sep 2017, 284, S1, 222-222.IF=4.530; Q1

98. Vladoiu S., Botezatu A., Anton G., Manda D., Paun D.L., Oros S., Rosca R., Draganescu D.D. The involvement of VDR promoter methylation, CDX-2 VDR polymorphism and vitamin D levels in male infertility. Acta Endocrinologica-Bucharest Jul-Sep 2017, 13, doi:10.4183/aeb.2017.294.IF=0.411; Q4

97. Rosca A., Anton G., Botezatu A., Temereanca A., Ene L., Achim C., Ruta S. Mir-29a associates with viro-immunological markers of HIV infection in treatment experienced patients. Journal of Medical Virology Dec 2016, 88,doi:10.1002/jmv.24586.IF=1.935; Q3

96.  Bostan M., Mihaila M., Hotnog C., Bleotu C., Anton G., Roman V., Brasoveanu L.I. Modulation of apoptosis in colon cancer cells by bioactive compounds. Colorectal Cancer – From Pathogenesis to Treatment, Sep 2016, doi:10.5772/63382.

95. Mihai S., Codrici E., Popescu I.D., Enciu A.M., Rusu E., Zilisteanu D., Albulescu R., Anton G., Tanase C. Proteomic biomarkers panel: New insights in chronic kidney disease. Disease Markers Sep 2016, 2016, doi:10.1155/2016/3185232.IF=2.348; Q2

94. Vladoiu S., Draganescu D.D., Botezatu A., Anton G., Oros S., Paun D.L., Ianas O., Rosca R., Badiu C. Correlations between polymorphisms of estrogen 1, vitamin d receptors and hormonal profile in infertile men. Acta Endocrinologica-Bucharest Apr 2016, 12, doi:10.4183/aeb.2016.137.IF=0.250; Q4

93. Plesa A., Iancu I.V., Botezatu A., Huica I., Stoian M., Anton G. The involvement of epigenetic mechanisms in HPV-induced cervical cancer; Human PapillomavirusResearch in a Global Perspective. Mar 2016, 191-239. doi:10.5772/62833

92. Iancu I., Botezatu A., Plesa A., Huica I., Socolov D., Anton G. H19 and malat1 lncRNA expression level as prognostic factors in cervical oncogenesis. Gynecological Endocrinology Feb 2016, 32, 113-113.IF=1.585; Q4

91. Botezatu A., Puiu M., Cucu N., Diaconu C.C., Badiu C., Arsene C., Iancu I.V., Plesa A., Anton G. Comparative molecular approaches in prader-willi syndrome diagnosis. Gene Jan 2016, 575, doi:10.1016/j.gene.2015.08.058.IF=2.415; Q3

90.  Schipor S., Vladoiu S., Baciu A.E., Niculescu A.M., Caragheorgheopol A., Iancu I., Plesa A., Popescu A.I., Manda D. A comparative analysis of three methods used for RNA quantitation. Romanian Reports in Physics Jan 2016, 68, 1178-1188.IF=1.467; Q2

89. Comanescu C., Bleotu C., Huica I., Radulescu M., Grancea C., Anton G. Non-invasive method for the evaluation of lL-6 and IL-10 levels in patients with chronic hepatitis c. Romanian Biotechnological Letters Nov-Dec 2015, 20, 11018-11024.IF=0.381; Q4

88. Botezatu A., Iancu I.V., Plesa A., Diaconu C.C., Anton G., Florea R., Ilie V., Sorop A., Bacalbasa N., Tica V., Duda D.G., Dima S.O., Popescu I. Deregulation b-catenin gene expression in pancreatic cancer. Pancreas Nov 2015, 44, 1362-1363.IF=2.738; Q2

87. Botezatu A., Iancu I.V., Manda D., Plesa A., Huica I., Vladoiu S., Anton G., Badiu C. DNA methylation profiles of tumor suppressor genes promoters involved in papillary thyroid carcinoma. European Journal of Cancer Sep 2015, 51, S10-S10, doi:10.1016/s0959-8049(16)30031-4.IF=5.531; Q1

86. Mihai S., Rusu E., Zilisteanu D., Codrici E., Popescu I.D., Enciu A.M., Albulescu R., Voiculescu M., Anton G., Tanase C. Proteomics and metabolomics in early diagnosis and monitoring of patients with chronic kidney disease. Febs Journal Jul 2015, 282, 196-196.IF=4.237; Q1

85. Iancu I.V., Botezatu A., Plesa A., Huica I., Socolov D., Anton G. Histone lysine demethylases as epigenetic modifiers in HPV-induced cervical neoplasia. Romanian Biotechnological Letters Mar-Apr 2015, 20, 10236-10244.IF=0.381; Q4

84. Botezatu A., Bleotu C., Nastase A., Anton G., Bacalbasa N., Duda D., Dima S.O., Popescu I. Epigenetic silencing of GNMT gene in pancreatic adenocarcinoma. Cancer Genomics & Proteomics Jan-Feb 2015, 12, 21-30.IF=2.800; Q2

83. Rotaru M., Iancu G., Mihalache M., Anton G., Morariu S. Α-HPV positivity analysis in a group of patients with melanoma and non-melanoma skin cancers. Revista Romana De Medicina De Laborator Dec 2014, 22, doi:10.2478/rrlm-2014-0044.IF=0.239; Q4

81. Botezatu A., Bleotu C., Nastase A., Anton G., Bacalbasa N., Duda D., Dima S.O., Popescu I. Epigenetic silencing of GNMT gene in pancreatic adenocarcinoma. Pancreas Nov 2014, 43, 1346-1346.IF=2.959; Q2

80. Plesa A., Iancu I.V., Botezatu A., Huica I., Manda D., Vladoiu S., Anton G., Badiu C.V. Analyses of microrna-34b and c-myc expression profile in papillary thyroid carcinoma. Febs Journal Sep 2014, 281, 262-262.IF=4.001; Q2

79.  Iancu I.V., Plesa A., Botezatu A., Huica I., Anton G., Manda D., Brehar A., Badiu C.V. Global DNA methylation evaluation and dnmt1 gene expression in thyroid neoplasia. Febs Journal Sep 2014, 281, 302-302.IF=4.001; Q2

78. Botezatu A., Bleotu C., Nastase A., Anton G., Bacalbasa N., Duda D.G., Dima S.O., Popescu I. Cpg islands promoter methylation the main cause for gnmt gene decreased expression in pancreatic adenocarcinoma. Febs Journal Sep 2014, 281, 299-299.IF=4.001; Q2

77. Cernescu E., Ruta S., Botezatu A., Anton G., Cernescu C. Impact of education level and life-style related factors on high-risk human papilomaviruses infections. Romanian Biotechnological Letters Mar-Apr 2014, 19, 9272-9279.IF=0.404; Q4

75. Rusanu C., Botezatu A., Huica I., Iancu I., Plesa A., Anton G. Qualitative and quantitative mtdna alterations in HPV16-positive cervical neoplasia. European Journal of Cancer Sep 2013, 49, S715-S715.IF=4.819;Q1

74. Rusanu C.D., Iancu I., Botezatu A., Huica I., Anton G. Mitochondrial non-coding RANs (ncRNAs) expression in human papilloma virus-related cervical lesions. Febs Journal Jul 2013, 280, 41-41.IF=3.986;Q2

73.  Iancu I.V., Botezatu A., Plesa A., Huica I., Socolov D., Anton G. Study on the expression pattern of histone demethylases in HPV-induced cervical lesions. Febs Journal Jul 2013, 280, 382-382.IF=3.986;Q2

72. Botezatu A., Socolov D., Iancu I.V., Huica I., Plesa A., Ungureanu C., Anton G. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and promoter methylation in cervical oncogenic lesions and cancer. Journal of Cellular and Molecular Medicine Apr 2013, 17, 543-549, doi:10.1111/jcmm.12032.IF=3.698;Q2

71. Bleotu C., Chifiriuc M.C., Grigore R., Grancea C., Popescu C.R., Anton G., Cernescu C. Investigation of Th1/Th2 cytokine profiles in patients with laryngo-pharyngeal, HPV-positive cancers. European Archives of Oto-Rhino-Laryngology Feb 2013, 270, doi:10.1007/s00405-012-2067-7.IF=1.608;Q2

70. Bleotu C., Pircalabioru G., Dragusel R., Aldea I.M., Anca B., Banu O., Mihaescu G., Cernescu C.E., Diaconu C.C. Modulation of interaction between virus and eukaryotic host by exposure to S. aureus bacterial soluble fractions. Current Organic Chemistry Jan 2013, 17, doi:10.2174/1385272811317020009. IF=2.537;Q2

68. Arsene C., Zarnescu O., Puiu M., Anton G., Botezatu A., Popa C., Cucu N. Epigenetic approach of Prader-Willi syndrome diagnosis in Romanian population. Romanian Biotechnological Letters Nov-Dec 2012, 17, 7846-7852.IF=0.363;Q4

67. Rusanu C., Botezatu A., Iancu I.V., Huica I., Plesa A., Anton G. Mitochondrial polymorphisms as possible predictive markers in Human Papilloma Virus (HPV)-related cervical lesions. European Journal of Cancer Jul 2012, 48, S162-S163, doi:10.1016/s0959-8049(12)71331-x.IF=5.061;Q1

66. Rusanu C., Botezatu A., Iancu I., Huica I., Plesa A., Anton G. Mitochondrial DNA mutations and copy number alteration in breast cancer patients from Romania. European Journal of Cancer Mar 2012, 48, S119-S120.IF=5.061;Q1

65. Huica I., Botezatu A., Iancu I.V., Lupeanu E., Anton M., Goia C.D., Anton G. Genetic and epigenetic aspects in cardio-vascular disease and ageing. Romanian Biotechnological Letters Sep-Oct 2011, 16, 6488-6496.IF=0.349;Q4

64. Iancu I.V., Plesa A., Botezatu A., Huica I., Anton G. SiRNA inhibition of E6ap expression in cervical cancer cells. Febs Journal Jun 2011, 278, 329-329.IF=3.790;Q2

63. Huica I., Iancu I.V., Botezatu A., Anton M., Lupeanu E., Anton G. Investigation of mir-21 and TGF-β1 gene expression levels in blood circulation of patients with cardiac disease. Febs Journal Jun 2011, 278, 285-285.IF=3.790;Q2

62. Aldea I.M., Bleotu C., Brehar F., Botezatu A., Diaconu C., Chivu M., Lisievici M., Gorgan R.M., Anton G. Investigation of some epigenetic markers in glioblastoma. Annals of Oncology May 2011, 22, 43-43. IF=6.425;Q1

61. Botezatu A., Goia-Rusanu C.D., Stanescu A.D., Iancu I.V., Popa E., Nistor E., Huica I., Anton G., Plesa A. WWP1, TGF beta and KLF5 gene expression levels as new possible factors involved in cervical oncogenesis. Revista Romana De Medicina De Laborator Mar 2011, 19, 47-54.IF=0.091;Q4

60.  Mihai M., Valentin N., Anton G., Coralia B., Nora M., Demetra S. High prevalence of fluoroquinolones resistance in ureaplasma and mycoplasma strains isolated from infertile women under initial evaluation in north-east Romania. Romanian Biotechnological Letters Jan-Feb 2011, 16, 5858-5862.IF=0.349;Q4

58. Anton G., Peltecu G., Socolov D., Cornitescu F., Bleotu C., Sgarbura Z., Teleman S., Iliescu D., Botezatu A., Goia C.D., Huica I., Anton A.C. Type-specific human papillomavirus detection in cervical smears in Romania. Apmis Jan 2011, 119, 1-9, doi:10.1111/j.1600-0463.2010.02641.x.IF=1.991;Q3

57. Anton M., Anton G., Muraru M. Endothelyal dysfunction in patients with metabolic syndrom and hepatic disease. European Heart Journal Supplements Oct 2010, 12, F81-F82.IF=2.153;Q2

56. Ungureanu C., Socolov D., Anton G., Mihailovici M.S., Teleman S. Immunocytochemical expression of p16ink4a and HPV l1 capsid proteins as predictive markers of the cervical lesions progression risk. Romanian Journal of Morphology and Embryology Jul-Sep 2010, 51, 497-503.IF=0.381;Q4

55.  Goia C.D., Iancu I.V., Socolov D., Botezatu A., Lazaroiu A.M., Huica I., Plesa A., Anton G. The expression of cell cycle regulators in HPV – induced cervical carcinogenesis. Romanian Biotechnological Letters Jul-Aug 2010, 15, 5376-5383.IF=0.219;Q4

54. Cucu N., Anton M., Stambuli D., Botezatu A., Arsene C., Lupeanu E., Anton G. Cardiovascular diseases: A link between genetic, epigenetic and metabolic factors. Cardiovascular Research Jul 2010, 87, S72-S73.IF=6.051;Q1

53. Iancu I.V., Socolov D., Botezatu A., Plesa A., Ungureanu C., Goia C., Anton G. Expression of TGF-beta/SMADs signalling in human cervical cancers. Febs Journal Jun 2010, 277, 124-125.IF=3.129;Q2

52. Goia C.D., Botezatu A., Socolov D., Iancu I.V., Huica I., Plesa A., Anton G. The implication of mtDNA mutations in HPV-induced cervical carcinogenesis. Febs Journal Jun 2010, 277, 91-92.IF=3.129;Q2

51. Botezatu A., Iancu I.V., Goia C.D., Plesa A., Huica I., Socolov D., Anton G. Methylation status of mir-124a gene promoter and its tumor suppressor role in cervical oncogenesis. Febs Journal Jun 2010, 277, 154-155.IF=3.129;Q2

50. Anton G., Brasoveanu L.I., Socolov D., Botezatu A., Anton M., Goia C.D., Iancu I.V., Cucu N. Epigenetic regulation to anti-cancer drugs in HPV positive cell lines. Ejc Supplements Jun 2010, 8, doi:10.1016/s1359-6349(10)71083-1.IF=9.386;Q1

49. Anton M., Avram S., Muraru M., Lupeanu E., Bruckner I., Anton G. Aspects of endothelyal dysfunction in hypertensive patients with metabolic syndrom and hepatic disease. Journal of Hypertension Jun 2010, 28, doi:10.1097/01.hjh.0000379949.17457.34.IF=3.980;Q1

48. Teleman S., Ungureanu C., Socolov D., Grigore M., Anton A.C., Anton G. P16(ink4a), L1 HPV capsid protein and HPV genotyping in the uterine cervix. Acta Cytologica May-Jun 2010, 54, 428-428.IF=0.647;Q4

47 Puiu M., Rusu C., Badiu C., Dan D., Botezatu A., Cucu N. Prader-willi syndrome and diagnostic protocols: A preliminary study in Romania. Revista Romana De Medicina De Laborator Mar 2010, 18, 15-22.IF=0.113;Q4

46.  Bleotu C., Botezatu A., Goia C., Socolov D., Dragomir L., Popa E., Cornitescu F., Teleman S., Anton G. Htert expression as a potential diagnostic marker. Romanian Biotechnological Letters Jan-Feb 2010, 15, 4922-4930.IF=0.219;Q4

45. Anton M., Bruckner I., Muraru M., Lupeanu E., Anton G. Relation between adipocytokine values and renal failure in postmenopausal women with metabolic syndrome. International Journal of Cardiology Oct 2009, 137, doi:10.1016/j.ijcard.2009.09.385.IF=3.469;Q2

44. Anton M., Avram S., Purcarea F., Lupeanu E., Bruckner I., Muraru M., Anton G. Particular aspects of endothelial disorders in patients with metabolic syndrome. Journal of Hypertension Jun 2009, 27, S403-S403.IF=4.988;Q1

43. Socolov D., Anton G., Anton A.C., Anton E., Socolov R.V., Teleman S., Melinte A., Boiculese L., Stoian M. Electrosurgical loop excision/conisation for cervical intraepithelial neoplasia in an algorithm that excludes punch biopsy – a study of 210 cases. Chirurgia May-Jun 2009, 104, 295-301.

42. Dumache R., Puiu M., Anton G., Cucu N. Biomarker for the early detection of prostate cancer. Iubmb Life Mar 2009, 61, 370-370.IF=3.578;Q2

41. Cucu N., Anton G., Zarnescu O., Botezatu A., Albu C., Matei M., Ovidiu-Tanase A., Posea C. Epigenetic biomarkers linked with methyl group metabolism in mammary cancer diagnosis. Iubmb Life Mar 2009, 61, 358-358.IF=3.578;Q2

40.  Cucu N., Anton G., Botezatu A., Turcu I., Spiru L., Burlibasa L. DNA hypomethylating effect of a geriatric protective drug and correlations with epigenetic biomarkers of aging. Iubmb Life Mar 2009, 61, 361-361.IF=3.578;Q2

39. Cucu N., Anton G., Botezatu A., Puiu M., Dan D. Epigenetic method for the early diagnosis of Prader Willi syndrome. Iubmb Life Mar 2009, 61, 361-361.IF=3.578;Q2

38. Anton G., Socolov D.G., Botezatu A., Goja C.D., Anton M., Stanescu A.D., Plesa A., Teleman S. Human papilomavirus DNA and mRNAs – markers for cervical lesions progression. Iubmb Life Mar 2009, 61, 344-344.IF=3.578;Q2

37. Anton G., Socolov D., Sgarbură Z., Corniţescu F., Goia C.D., Iancu I.V., Pleşa A., Teleman S. DNA versus RNA methods for human papillomavirus detection in cervical samples. GINECO RO 2009, 5, 242-246.

36. Socolov D.G., Anton G., Anton E., Teleman S., Anton A.C., Carauleanu A., Socolov R. Human Papilloma virus distribution in patients from Moldova region. Gineco Ro Dec 2008, 4, 248-252.

35. Brasoveanu L.I., Anton G., Hirt M., Stoian M. Modulation by stimuli treatment of cam expression, proliferation and apoptosis associated to cervix tumor cells. Anticancer Research Sep-Oct 2008, 28, 3219-3219.IF=1.394;Q4

34. Anton G., Brasovearu L.I., Botezatu A., Lulial L., Mihai S., Cucu N. Saha anticancer activity through derepression effect on critical genes in HPV cell lines. Anticancer Research Sep-Oct 2008, 28, 3198-3199. IF=1.394;Q4

33. Plesa A., Goia C., Botezatu A., Bleotu C., Socolov D., Peltecu G., Cornitescu F., Anton G. Analysis of HPV DNA and p16 expression to predict prognosis in ascus, lsil and hsil in cervical swabs. Febs Journal Jun 2008, 275, 274-274. IF=3.139;Q2

32. Goia C.D., Bleotu C., Antipa C., Lupu A.R., Closca M., Ciocan O., Anton G. Epstein-Barr virus latent gene expression and EBNA promoter methylation in non-Hodgkin lymphoma patients. Febs Journal Jun 2008, 275, 103-103.IF=3.139;Q2

31. Botezatu A., Popa I., Welt L., Constantin M., Anton G. Epigenetic factors in oncogenesis. Febs Journal Jun 2008, 275, 102-102.IF=3.139;Q2

30. Bleotu C., Chivu M., Alexiu I., Anton G., Diakonu C.C., Neagu A., Cernescu C. New in vitro models for understanding molecular mechanism of oncogenesis. Febs Journal Jun 2008, 275, 329-329.IF=3.139;Q2

29. Anton M., Anton G., Sgarbura Z., Iliescu D., Bleotu C., Botezatu A., Goia C., Plesa A. E6 human papillomavirus type16 methylation in clinical specimens. Febs Journal Jun 2008, 275, 102-102.IF=3.139;Q2

27. Anton G., Socolov D., Bleotu C., Anton A.C., Anton M., Goia C., Botezatu A. Viral markers as prognostic factors of cervical lesions progression. Ejc Supplements Sep 2007, 5, 106-106, doi:10.1016/s1359-6349(07)70496-2.IF=2.709;Q2

26. Goia C.D., Closca M., Lupu A.R., Ciobanu A., Ciocan O., Anton M., Anton G. Apoptosis regulated protein levels and telomerase activity in high-grade non-hodgkin’s lymphomas. Febs Journal Jul 2007, 274, 177-177.IF=3.396;Q2

25. Botezatu A., Anton G., Burlibasa L., Cucu N. Genomic instability in human breast tumors through hypermethylation of tumor suppressor promoter genes (er alpha and rar beta). Febs Journal Jul 2007, 274, 76-76.IF=3.396;Q2

24. Anton G., Anton M., Plesa A., Bleotu C., Antipa E. P16 epigenetic alterations during cervical carcinogenesis. Febs Journal Jun 2006, 273, 227-228.IF=3.033;Q2

23. Bleotu C., Anton G., Plesa A., Chivu M., Alexiu I. Genomic plasticity is frequent in HPV-associated carcinogenesis. Febs Journal, Jun 2006; pp. 355-355.IF=3.033;Q2

22. Diaconu C.C., Bleotu C., Chivu M., Alexiu I., Petrusca D., Anton G., Achim R., Ruta S.M., Cernescu C. The development of larger cells that spontaneously escape senescence – a step during the immortalization of a human cancer cell line. Journal of Cellular and Molecular Medicine Jan-Mar 2004, 8, doi:10.1111/j.1582-4934.2004.tb00263.x.IF=2.153;N/A

21. Plesa A., Anton G., Diaconu C., Stoian M., Repanovici R., Cernescu C. Cloning and expression of the l1 major capsid protein of the human papillomavirus 18 in murine cells. International Journal of Molecular Medicine Dec 2003, 12, 1021-1026.IF=1.940;Q2

20. Mutiu A., Alexiu I., Chivu M., Petica M., Anton G., Bleotu C., Diaconu C., Popescu C., Jucu V., Cernescu C. Detection of human papillomavirus gene sequences in cell lines derived from laryngeal tumors. Journal of Cellular and Molecular Medicine Jan-Mar 2001, 5, doi:10.1111/j.1582-4934.2001.tb00137.x.

19. Repanovici R., Plesa A., Anton G. Transformation of Escherichia coli cells by ph 2.3 plasmid DNA treated with psoralens plus near-UV light. Journal of Photochemistry and Photobiology B-Biology Jan 1997, 37, doi:10.1016/s1011-1344(96)07326-5.IF=1.381;Q3

18. Popa L., Repanovici R., Iliescu R., Mutiu A., Sahnazarov N., Kittler L., Lober G. Effect of 8-methoxypsoralen or angelicin plus near uv-light on herpes-simplex virus viability and on the plaque-forming capacity of lambda-l47.1 phages. Studia Biophysica 1990, 135, 155-163.

17. Iliescu R., Calinoiu A., Repanovici R., Popa L.M., Lober G. Effect of ambazone on the multiplication and biological-activities of sendai virus. Studia Biophysica 1987, 117, 111-116.

16. Lober G., Popa L.M., Mihalache O., Repanovici R., Iliescu R., Ossman J., Cajal N. Effect of anthracycline antibiotics on the neuraminidase activity of Sendai virus. Studia Biophysica Dec 1986, 114, 231-238.

15. Popa L.M., Repanovici R., Iliescu R., Horer O., Kittler L. Interaction of psoralens with plasmid DNAs. Photobiochemistry and Photobiophysics Feb 1986, 10, 269-277.

14. Repanovici R., Iliescu R., Lober G., Cajal N., Popa L.M. Effect of some anthracycline antibiotics on the neuraminidase activity of Sendai virus and its isolated glycoproteins. Acta Virologica Dec 1985, 29, 499-504.

13. Popa L.M., Repanovici R., Iliescu R., Mihalache O., Cajal N. Some physicochemical and biological properties of egg-Sendai virus with altered hemagglutinin-neuraminidase protein. Acta Virologica Dec 1985, 29, 461-&.

12. Lober G., Repanovici R., Klarner R., Mihalache O., Romer W., Iliescu R., Horer O., Hanschmann H., Skalka M., Popa L.M. Influence of antitumor anthracycline antibiotics on membrane and DNA directed processes. Studia Biophysica 1984, 101, 103-119.

11. Lober G., Kittler L., Klarner R., Hradecna Z., Kleinwachter V., Balcarova Z., Skalka M., Koudelka J., Smekal E., Popa L., Beensen V. DNA-drug interactions. Studia Biophysica 1982, 88, 1-16.

10. Popa L.M., Repanovici R., Lober G. Interaction of violamycin antibiotics with nucleic-acids .3. Electrophoretic evidence for the binding of violamycin-bi to deoxyribonucleic-acid. Studia Biophysica 1981, 83, 113-122.

9. Popa L.M., Repanovici R., Iliescu R., Angelescu S. Isolation of plasmid-pbr313 and plasmid-pbr322 DNAs by different methods. Revue Roumaine De Biochimie 1980, 17, 279-&.

8. Popa L.M., Repanovici R. Specific alteration of Sendai virus glycoprotein subunits. Acta Virologica Jan 1979, 23, 21-31.

7. Repanovici R., Burducea O., Tasca O., Popa L.M. Effect of chemical reagents on ribosomes isolated from normal and influenza virus-infected chorioallantoic membranes. Revue Roumaine De Biochimie 1979, 16, 65-70.

6. Popa L.M., Repanovici R., Samuel I. Influence of the isolation procedure on the structure, neuraminidase and hemagglutinating activities of Sendai virus envelope glycoproteins. Acta Virologica Nov 1978, 22, 433-442

5. Repanovici R., Popa L.M. Capacity of toluidine blue fixation by various molecular-species of cellular ribosomal and transfer ribonucleic-acids. Revue Roumaine De Biochimie 1977, 14, 279-287.

4. Popa L.M., Repanovici R. Enhancement and stabilization effect of edta on Sendai virus neuraminidase activity. Acta Virologica 1977, 21, 280-287.

3. Popa L.M., Repanovici R., Samuel I., Portocala R. Specific cleavage of Sendai virus nucleocapsid protein subunits during virus storage. Archives of Virology Dec 1975, 48, doi:10.1007/bf01317427.

2. Popa L.M., Repanovici R., Samuel I., Smelt D., Portocala R. Identification of Sendai virus neuraminidase and hemagglutinin subunits. Febs Letters Mar 1975, 51, doi:10.1016/0014-5793(75)80904-5.

1. Dumitrescu M., Banarescu P., Popa L.M. Molecular-weights of ribosomal-RNAs from liver of several fish species. Studia Biophysica 1975, 52, 93-97.